August 27-30, 2025
Prague
The Argonautes
2025
Programme
| Wednesday, August 27, 2025 | |
|---|---|
| 12:30-14:20 | Registration |
| 14:20-14:30 | Welcome from organizers |
| Session 1 – Structural insights | |
| 14:30-14:50 | David Bartel, Whitehead Institute – MIT Target-directed microRNA degradation |
| 14:50-15:10 | Ian MacRae, Scripps Research A conserved PIWI silencing complex detects piRNA-target engagement |
| 15:10-15:30 | Daniel Lin, Whitehead Institute A menagerie of endogenous site architectures mediates mammalian target-directed miRNA degradation |
| 15:30-16:10 | Coffee break |
| 16:10-16:30 | Richard Stefl, CEITEC How Argonautes engage with their protein binding partners |
| 16:30-16:50 | Kotaro Nakanishi, Ohio State University Structural and functional study of Argonaute syndrome |
| 16:50-17:10 | Daan Swarts, Wageningen University Activation and inactivation of long-A prokaryotic Argonaute proteins |
| 17:10-17:30 | Lizaveta Pshanichnaya, IMB Mainz A role for the intrinsically disordered N-terminal region of WAGO-3 in small RNA selection |
| 17:30-18:00 | Coffee break |
| 18:00-18:30 | Poster flashtalks (posters 1-27) |
| 18:30-22:30 | Barbecue dinner & welcome party around posters |
| Thursday, August 28, 2025 | |
|---|---|
| Session 2 – Argonaute complexes | |
| 09:00-09:20 | Stefan Ameres, Max Perutz Labs Uridylation-triggered RNA decay promotes multiple-turnover RNA interference to enhance antiviral silencing in Drosophila |
| 09:20-09:40 | Yukihide Tomari, University of Tokyo A primitive piRNA surveillance system that broadly monitors the germline transcriptome |
| 09:40-10:00 | Donal O’ Carroll, University of Edinburgh Safeguarding germline immortality |
| 10:00-10:20 | Mandy Jeske, Heidelberg University Defining piRNA factor interaction networks across species |
| 10:20-11:00 | Coffee break |
| 11:00-11:20 | Joshua Mendell, University of Texas Mechanism and physiologic role of target-directed microRNA degradation |
| 11:20-11:40 | Eric Lai, Sloan Kettering Institute An effector of enhanced RNA silencing in Alas1 mutants |
| 11:40-12:00 | Julie Claycomb, University of Toronto Deciphering the sex-specific roles of C. elegans germline small RNA pathways |
| 12:00-12:20 | Edvardas Golovinas, Vilnius University Swiss army knife interaction modality between split long-B pAgos and their effectors |
| 12:20-12:40 | Stela Jelenic, IMBA Vienna How germ granule localization shapes Argonaute specificity and fidelity in small RNA loading |
| 12:40-14:00 | Lunch |
| Session 3 – Argonaute modifications and regulations | |
| 14:00-14:20 | Peter Brodersen, University of Copenhagen Looping for loading: A role of ARGONAUTE loops in reversible chaperone binding |
| 14:20-14:40 | Renee Ketting, IMB Mainz Proteases regulate the loading and activity of Argonaute protein WAGO-3 in C. elegans |
| 14:40-15:00 | Martin Simard, Laval University Uncovering regulatory mechanisms of Argonaute function in the animal microRNA pathway |
| 15:00-15:20 | Marc Friedländer, Stockholm University/SciLifeLab Protected by Argonautes? MicroRNAs in ancient and extinct animals |
| 15:20-16:00 | Coffee break |
| 16:00-16:20 | Katherine McJunkin, NIH/NIDDKD A lncRNA drives developmentally-timed decay of all members of an essential microRNA family |
| 16:20-16:40 | Gunter Meister, University of Regensburg Interactions and modifications navigating AGO2 through small RNA-guided silencing cycles |
| 16:40-17:00 | Mo-Fang Liu, Shanghai Institute of Biochemistry & Cell Biology MIWI/piRNAs are programmed to enter the nucleus to silence meiotic genes in late spermatocytes |
| 17:00-17:20 | Aishe Sarshad, University of Gothenburg Nuclear AGO2 supports influenza A virus replication through type-I interferon regulation |
| 17:20-18:00 | Coffee break |
| 18:00-18:30 | Poster flashtalks (posters 28-55) |
| 18:30-19:30 | Dinner |
| 19:30-22:00 | Poster session with snacks & drinks |
| 22:00 – ?? | Argonaute music party |
| Friday, August 29, 2025 | |
|---|---|
| Session 4 – Silencing mechanisms & biological roles | |
| 09:00-09:20 | Victor Ambros, University of Massachusetts MicroRNAs contribute to multi-dimensional regulation of LIN-28 temporal expression dynamics in C. elegans |
| 09:20-09:40 | Amy Pasquinelli, University of California, San Diego Less Stress with miRISC |
| 09:40-10:00 | Germano Cecere, Institut Pasteur Soma-to-germline miRNA inheritance via yolk promotes stress resilience in progeny |
| 10:00-10:20 | Jack Bravo, ISTA Anti-plasmid immunity by pAgo-helicase/nuclease systems |
| 10:20-10:40 | Mindaugas Zaremba, Vilnius University Mechanism of action of SPARDA defense system |
| 10:40-11:20 | Coffee break |
| 11:20-11:40 | Phil Zamore, UMass Chan Medical School Mouse pachytene piRNAs persist in evolution because target cleavage by a tiny minority of piRNAs improves sperm fitness |
| 11:40-12:00 | Yehu Moran, Hebrew University of Jerusalem Characterizing the role of the Argonaute regulator ZSWIM8 in Cnidaria |
| 12:00-12:20 | Ronald van Rij, Radboud University Medical Center Nonredundant functions of mosquito PIWI proteins |
| 12:20-12:40 | Zuzana Loubalova, NIH/NIDDK Signatures of cooption in mammalian pachytene piRNAs |
| 12:40-13:00 | AGO alliance presentation |
| 13:00-14:10 | Lunch & family posters |
| 14:10-14:30 | Reina Komiya, Okinawa Institute of Science and Technology Reproductive Argonaute-mediated non-coding RNA regulation in rice |
| 14:30-14:50 | David Corey, University of Texas Applying Chimeric eCLIP to Nuclear RNAi |
| 14:50-15:10 | Amy Buck, University of Edinburgh Forms and functions of Argonaute transmission between cells |
| 15:10-15:30 | Ange Dussutour, Institut Sophia-Agrobiotech Secretion of small non-coding RNA as new effectors in plant-nematode interaction |
| 15:30-19:00 | Time off & transfer to Kolkovna |
| 19:00-22:00 | Dinner at Kolkovna downtown |
| Saturday, August 30, 2025 | |
|---|---|
| Session 5 – Argonautes in disease | |
| 09:00-09:20 | Davor Lessel, University of Regensburg Argonaute/Lessel-Kreienkamp syndrome: novel clinical, genetic and mechanistic insights |
| 09:20-09:40 | Astrid Haase, NIH/NIDDK Guardians of the germline: PIWI-clade Argonautes and their role in fertility |
| 09:40-10:00 | Gaspare La Rocca, University of Palermo Global inhibition of microRNA function impairs tumor growth and improves response to therapy |
| 10:00-10:20 | Jinju Han, KAIST AGO1 in neural progenitor cells orchestrates brain development and sociability via the LIN28A-REELIN axis |
| 10:20-11:00 | Coffee break |
| 11:00-11:20 | Amelie Piton, IGBMC Clinical and molecular characterization of Argonaute syndrome caused by nonsynonymous variants in human AGO1 gene |
| 11:20-11:40 | Hans-Jürgen Kreienkamp, Universitätsklinikum Hamburg-Eppendorf Functional analysis of missense variants in AGO2 causing Lessel-Kreienkamp syndrome (Leskres) |
| 11:40-12:00 | Clément Carré, Institut de Biologie Paris-Seine – Sorbonne Université Modeling human Argonaute-1 (hAGO1) mutations associated with intellectual disability in drosophila melanogaster |
| 12:00-12:20 | Anna Zinovyeva, Kansas State University Functional characterization of Argonaute syndromes variants in Caenorhabditis elegans |
| 12:20-12:40 | Clarisse Delvallée, IGBMC Deciphering pathophysiology of Argonaute syndrome, caused by nonsynonymous variants in human AGO1 gene, using transcriptomic cross analysis in 2D and 3D in vitro models of brain development |
| 12:40-14:00 | Closing & departures & boxed lunch |
| 13:30-17:00 | AGO syndrome patients workshop |
| 17:00-22:00 | Post-conference chilling out Na tý louce zelený |
Detailed information about the meeting can be found in the meeting manual.