August 27-30, 2025
Prague
Dear colleagues,
Argonaute proteins are found in all kingdoms of life and they exert their function through binding to specific classes of small non-coding RNAs. Generally, the small RNAs guide Argonaute proteins to target nucleic acids by sequence complementarity. The mechanistic consequences of such RNA-guided interactions differ across evolutionary conserved Argonaute clades and diverse Argonaute-dependent regulatory pathways have been identified. While some of these pathways have been studied extensively in the past decades, specific aspects remain rather elusive. Furthermore, Argonaute proteins have been implicated in many cellular pathways and exciting findings have been reported in recent years ranging from cellular defense mechanisms of prokaryotic Argonaute proteins to disease causing mutations in human Argonaute proteins. The third edition of the “Argonautes” conference covers all aspects of Argonaute protein structure, function and regulation in a broad range of organisms ranging from prokaryotes and plants to flies, worms and mammals. This time in Prague, we will follow the grassroot tradition of the meeting in order to bring together Argonaute enthusiasts and provide them with time and space to exchange knowledge and ideas about Argonautes’ mechanisms and functions.
The exciting scientific programme includes sessions dedicated to:
- Structural insights into Argonaute biology
- Argonaute effector complexes: formation, composition, function
- Argonaute-mediated post-transcriptional silencing
- Argonaute-mediated transcriptional silencing and DNA cleavage
- Argonautes‘ post-translational modifications and regulations
- Argonautes in health and disease
Invited Speakers
Victor Ambros, University of Massachusetts, Worcester, USA
Stefan Ameres, Max Perutz Labs, Vienna, Austria
David Bartel, Whitehead Institute – MIT, Cambridge, USA
Peter Brodersen, University of Copenhagen, Copenhagen, Denmark
Amy Buck, University of Edinburgh, Edinburgh, UK
Germano Cecere, Institut Pasteur, Paris, France
Julie Claycomb, University of Toronto, Toronto, Canada
David Corey, University of Texas, Dallas, USA
Tomas Duchaine, McGill Unversity, Montreal, Canada
Dina Grohmann, University of Regensburg, Regensburg, Germany
Astrid Haase, NIDDK, Bethesda, USA
Karina Jouravleva, LBMC, Lyon, France
Rene Ketting, Institute of Molecular Biology, Mainz, Germany
Reina Komiya, Okinawa Institute of Science and Technology, Okinawa, Japan
Eric Lai, Sloan Kettering Institute, New York, USA
Gaspare La Rocca, University of Palermo, Palermo, Italy
Davor Lessel, University of Regensburg, Regensburg, Germany
Ian MacRae, Scripps Research, La Jolla, USA
Katherine McJunkin, NIDDK, Bethesda, USA
Gunter Meister, University of Regensburg, Regensburg, Germany
Yehu Moran, Hebrew University of Jerusalem, Jerusalem, Israel
Kotaro Nakanishi, Ohio State University, Columbus, USA
Donal O’Carroll, University of Edinburgh, Edinburgh, UK
Amy Pasquinelli, University of California, San Diego, San Diego, USA
Amelie Piton, IGBMC, Illkirch, France
Martin Simard, Laval University, Quebec, Canada
Richard Stefl, Central European Institute of Technology (CEITEC), Brno, Czechia
Petr Svoboda, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia
Daan Swarts, Wageningen University, Wageningen, Netherlands
Yukihide Tomari, University of Tokyo, Tokyo, Japan
Joana Vidigal, National Cancer Institute, Center for Cancer Research, Bethesda, USA
Phillip Zamore, UMass Chan Medical School, Worcester, USA
Organisers
Julie Claycomb, University of Toronto, Toronto, Canada
Dina Grohmann, University of Regensburg, Regensburg, Germany
Gunter Meister, University of Regensburg, Regensburg, Germany
Petr Svoboda, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia
Partners & Sponsors
